• Yunzhi Li, Ying Ruan, Xiangjie Zhai, Junjie Ye, Yujie Xiao, Jiawei Liang, and Ni Zhu.
• Key Laboratory of Environmental Related Diseases and One Health, School of Basic Medicine Sciences/School of Pharmacy/National Demonstration Center for Experimental (General Practice) Education, Xianning Medical College, Hubei University of Science and Technology, Xianning, China.
• Medicine (Baltimore). 2024 Jun 14; 103 (24): e38550e38550.

BackgroundEnteroviruses-infected hand, foot, and mouth disease (HFMD) seriously threatens human health. This study aimed to analyze the research status, hotspots, and frontiers of HFMD.MethodsPublications on HFMD between January 1, 2006, and January 31, 2023, were retrieved from the Web of Science Core database. Bibliometric tools, including CiteSpace, VOSviewer, R package "Bibiometrix," SCImago Graphica, and Charticulator, were utilized to analyze and visualize the data.ResultsA total of 1860 articles from 424 journals, involving 8815 authors from 64 countries and 1797 institutions were analyzed. The number of studies on HFMD has shown an increasing trend over the past 18 years, with an annual increase observed since 2006, which is particularly prominent after 2010. Research in this field has centered on the Asian region. Notably, the research hotspots were mainly focused on vaccines, epidemiology, and pathogenesis of HFMD. Among the researchers in this field, Zhang Yong emerged as the most prolific author, while Xu Wenbo had the most significant influence. The Chinese Academy of Sciences was the most productive institution, and China was the most productive country for HFMD research.ConclusionBy bibliometric analysis, researchers in the HMFD field can efficiently identify and visually represent their research focus and limitations. In the future, it is crucial to maintain ongoing surveillance of HFMD outbreaks and their pathogenic changes. Additionally, future research should extensively explore the molecular mechanisms underlying Enteroviruses-induced HFMD with a focus on developing vaccines and therapies.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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