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- Weihua Yuan, Yanyan Ma, and Hui Zhang.
- School of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China.
- Medicine (Baltimore). 2024 Jun 14; 103 (24): e38496e38496.
AbstractAs a subtype of the 5-hydroxytryptamine (5-HT) receptor, 5-HT1A receptors are involved in the pathological process of psychiatric disorders and is an important target for antidepressants. The research groups focus on these area have tried to design novel compounds to alleviate depression by targeting 5-HT1A receptor. The heterocyclic structures is an important scaffold to enhance the antidepressant activity of ligands, including piperazine, piperidine, benzothiazole, and pyrrolidone. The current review highlights the function and significance of nitrogen-based heterocyclics 5-HT1AR represented by piperazine, piperidine, benzothiazole, and pyrrolidone in the development of antidepressant.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.
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