• Yin-Ling Chen, Yong-Chao Qiao, Xin-Nan Song, Wei Ling, Hai-Lu Zhao, and Xiao-Xi Zhang.
• Center of Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin, China.
• Medicine (Baltimore). 2017 May 1; 96 (20): e6915e6915.

RationaleLatent autoimmune diabetes in adults (LADA) refers to an autoimmune disorder characterized with detectable islets antibodies in the early diagnosis and increased autoimmune beta-cell failure progression. Notably, this kind of diabetes seems to be confused with other phenotypic diabetes.Patient ConcernsA young woman suffered an emotional exhaustion-induced LADA, showing asthenia, polydipsia, polyuria, and visible weight loss. The patient emotionally ended a 14-year romantic relationship, leading to the emotional flooding.DiagnosesThe data from physical examination and laboratory tests exhibited as follows: glutamic acid decarboxylase antibody (GADA) = 63.83 U/mL, the fasting blood glucose (FBG) = 13.3 mmol/L, and glycated haemoglobin (HbA1c) = 10.9%. According to levels of GADA, the patient was diagnosed as LADA.InterventionsThe patient was clinically treated with insulin for 3-month. Then, running, diet-control, and emotional treatment were combined, such as the patient started a new relationship.OutcomesAn emotional recovery initiated from a new romantic relationship and a baby, showing normal levels of GAD65 (27.007 IU/mL) and FBG (5.46) mmol/L.LessonsThe emotional exhaustion might play a significant role in induction of LADA. It is important that individuals should maintain optimism, cheer, and a positive attitude.

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