• Ming Liu, Yueping Zhao, and Lianxue Jiang.
• Chengdu Integrated Traditional Chinese Medicine and Western Medicine Hospital, Chengdu First People's Hospital, Chengdu, Sichuan, China.
• Medicine (Baltimore). 2024 Jun 21; 103 (25): e38474e38474.

AbstractThe link between celiac disease (CeD) and thyroid dysfunction has been investigated. However, it is uncertain if CeD is causally linked to thyroid dysfunction. A 2-sample Mendelian randomization study was conducted to ascertain the causal connection between CeD and thyroid dysfunction. Using data from the FinnGen Consortium, a 2-sample Mendelian randomization study was conducted to look at the connection between thyroid dysfunction and CeD. Another replication of the data from the UK Biobank was subsequently performed to confirm our findings. Furthermore, a sequence of sensitivity analyses was performed. The inverse variance weighting technique demonstrates that genetically determined CeD is substantially linked with hypothyroidism, thyrotoxicosis, Graves' disease, and free thyroxine. However, no significant associations were found between CeD and thyroid-stimulating hormone or thyroiditis. Moreover, we achieve the same results in duplicate datasets, which increases the reliability of our findings. This study suggests that CeD and thyroid dysfunction are linked, and it gives theoretical support and new ways of thinking about how to diagnose and treat both conditions.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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