• Medicine · Jun 2024

    Observational Study

    Characteristics of COVID-19 comorbidities and severity profiles among pregnant women from a single-center cross-sectional study.

    • Amillia Siddiq, Vischila Geray D'lamanda, Muhamad Dwi Anggi, Lulu Eva Rakhmilla, Akhmad Yogi Pramatirta, Dini Pusianawati, Leni Lismayanti, Anggraini Widjajakusuma, Annisa Dewi Nugrahani, and Dhanny Primantara Johari Santoso.
    • Department of Obstetrics and Gynecology, Faculty of Medicine, University of Padjadjaran - Dr. Hasan Sadikin General Hospital Bandung, West Java, Indonesia.
    • Medicine (Baltimore). 2024 Jun 21; 103 (25): e38636e38636.

    AbstractThe study aimed to determine the characteristics of comorbidities, association between comorbidities and coronavirus disease 2019 (COVID-19), as well as characteristics of COVID-19 severity among pregnant women at a tertiary hospital in Bandung. We conducted a cross-sectional study by taking secondary data between January 2020 and December 2021 involving 278 pregnant women aged 16 to 45 years that confirmedly diagnosed with COVID-19 via RT-PCR. We collected information from the medical record on severity and comorbidities. The admission C-reactive protein (CRP) profiles were compared between the severe and nonsevere COVID-19 patients. This study employed bivariate analysis, t test, and multivariate analysis with logistic regression models. Of the 278 data included in this study, 120 cases had comorbidities. Most patients were asymptomatic (82%). Obesity was the most common comorbid proportion. Only hypertension as comorbid showed a significant association with symptomatic or asymptomatic COVID-19 (<0.05). Pregnant women with hypertension were 6 times more likely to show symptoms than those without hypertension (OR = 6.092; 95% CI 3.103-11.962). Pregnant women with comorbidities were at higher risk of cesarean sections and stillbirth. The CRP levels which were found to have statistically significant association with COVID-19 severity (<0.05). The domination of asymptomatic COVID-19 in pregnant women was found in this study. Hypertension comorbid has a significant association with COVID-19 symptoms. Maternal and neonatal outcomes appear to be influenced by maternal comorbidities. Moreover, the CRP levels were found to be significant risk factors for COVID-19 severity in pregnant women that might have association with comorbidities.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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