• Amira Mohamed Taha, Qasi Najah, Mohamed Mosad Omar, Khaled Abouelmagd, Mohammed Ali, Mohammed Tarek Hasan, Sahar A Allam, Yasser A Hamam, Roua Arian, and Mohamed Abd-ElGawad.
• Faculty of Medicine, Fayoum University, Fayoum, Egypt.
• Medicine (Baltimore). 2024 Jun 21; 103 (25): e38525e38525.

BackgroundSepsis remains a leading cause of death worldwide. In this context, heparin-binding protein (HBP) has emerged as a possible biomarker, drawing significant attention for its diagnostic and prognostic usefulness in septic patients. Despite this advancement, the literature yields conflicting results. This study is intended to critically evaluate the diagnostic and prognostic value of HBP in critically ill septic patients.MethodsWe searched multiple databases, including PubMed, SCOPUS, Web of Science, and EBSCO, to identify relevant studies on April 27, 2023. We included studies investigating sepsis or its severe outcomes that reported HBP levels and the required data to create 2 × 2 tables. We used R version 4.2.2 and R Studio to analyze the pooled diagnostic accuracy outcomes. The diagmeta package was utilized to calculate the optimum cutoff value.ResultsIn our meta-analysis, we incorporated 28 studies including 5508 patients. The analysis revealed that HBP has a sensitivity of 0.71 (95% CI: 0.60; 0.79) and a specificity of 0.68 (95% CI: 0.51; 0.81) in diagnosing sepsis, respectively. HBP demonstrated moderate prognostic accuracy for mortality at a cutoff value of 161.415 ng/mL, with a sensitivity and specificity of 72%, and for severe sepsis outcomes at a cutoff value of 58.907 ng/mL, with a sensitivity and specificity of 71%.ConclusionOur findings indicate a relatively moderate diagnostic and prognostic accuracy of HBP for sepsis. Future studies are required to verify the accuracy of HBP as a biomarker for sepsis.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

16 keywords...

hide…