• Sangam Shah, Krishna Dahal, Prativa Subedi, Sangharsha Thapa, Prince Mandal, Ashutosh Kashyap, Himal Bikram Bhattarai, Ashwini Gupta, Sarita Dhakal, Sweta Singh, and Swati Chand.
• Tribhuvan University, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
• Medicine (Baltimore). 2024 Jun 21; 103 (25): e38619e38619.

BackgroundIn patients with ischemic stroke (pwIS), cardiac complications have been observed in observational studies. We conducted a systematic review and meta-analysis to investigate the arrhythmias and heart failure in pwIS.MethodsUp until September 2023, we searched for case-control, cross-sectional, or cohort studies in 4 databases. For case-control/cross-sectional studies, odds ratios (OR) were determined using a random-effects model meta-analysis, while hazard ratios (HR) were calculated for cohort studies, and 95% confidence intervals (CIs) were pooled in the meta-analysis.ResultsIn the meta-analysis, we incorporated 5 studies: 2 cohort studies, 2 case-control studies, and 1 cross-sectional study. In all, 81,181 controls and 25,544 pwIS were included in this investigation. The combined OR for case-control studies of arrhythmias was estimated to be 1.86 (95% CI: 0.70-4.94, P = .21), HR for cohort studies of arrhythmias to be 4.2 (95% CI: 1.49-12.01, P < .05), and for cohort studies of heart failure to be 2.9 (95% CI: 2.65-3.18, P < .05), suggesting that pwIS may be more likely to experience cardiac complications.ConclusionOur results revealed that there is a comparatively higher risk of cardiac complications in pwIS; however, more research is needed to evaluate the risk of cardiac complications in pwIS.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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