• Dengshun Wang, Hongwei Yu, Tong Gao, Haibin Lu, and Yu'e Wang.
• Department of Oral and Maxillofacial Surgery, Zhongshan Hospital Affiliated to Dalian University, Dalian, Liaoning Province, People's Republic of China.
• Medicine (Baltimore). 2024 Jun 21; 103 (25): e38543e38543.

BackgroundFibrolipoma of the lower lip is an uncommon condition with limited documentation in the literature. This paper provides updated insights into oral and maxillofacial lipomas through a detailed case report and comprehensive literature review, discussing clinical features, pathogenesis, diagnostic approaches, histopathology, and therapeutic strategies.Case PresentationA 54-year-old female presented with a painless, enlarging mass on the inner aspect of her right lower lip, first noticed 2 years prior. The mass, now the size of a peanut, interfered with her eating and speech. Physical examination revealed a 2.0 × 2.5 × 1.0 cm mass beneath the mucous membrane of the right lower lip. It was firm, well-demarcated, and mobile. Surgical excision was performed, and histopathological analysis confirmed the diagnosis of a lower lip fibrolipoma. The lesion was successfully removed without recurrence.ConclusionLipomas in the oral and maxillofacial regions are rare, slow-growing benign tumors, particularly within the lips. Although their diagnosis is straightforward based on clinical presentation, histopathological confirmation is essential. Surgical resection remains the treatment of choice, with excellent prognostic outcomes.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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