• J Formos Med Assoc · Nov 2024

    Serological responses to COVID-19 vaccination in patients with chronic liver diseases.

    • Yu-Shan Huang, Szu-Min Hsieh, Feng-Chiao Tsai, Chien-Chih Tung, Hung-Chih Yang, Sui-Yuan Chang, Jann-Tay Wang, Chun-Jen Liu, Tung-Hung Su, and Jia-Horng Kao.
    • Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.
    • J Formos Med Assoc. 2024 Nov 1; 123 (11): 119411971194-1197.

    AbstractLongitudinal analysis of antibody responses following three-dose COVID-19 vaccination in patients with chronic liver disease (CLD) has been limited. From August 2021 to February 2023, sequential anti-SARS-CoV-2 spike IgG titers were determined in 45 patients with CLD who received two or three doses of COVID-19 vaccine. The geometric mean of anti-spike IgG at four weeks after the second and third doses were 1313.16 BAU/mL and 3042.29 BAU/mL, respectively, and it decreased significantly from four to 24 weeks after the second (1313.16 vs. 198.42 BAU/mL, p = 0.002) and the third (3042.29 vs. 636.71 BAU/mL, p < 0.001) dose. The anti-spike IgG titers in participants receiving prime-boost homologous mRNA vaccines (BNT162b2 or mRNA-1273) were comparable between participants with and those without significant liver fibrosis at each follow-up time point. This study demonstrated a notable decrease in anti-spike IgG after completion of the vaccination schedule in patients with CLD, highlighting the importance of additional booster doses.Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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