• Angela Lucia Balocco, Nicolas Gautier, Sam Van Boxstael, Ana M López, Michele Carella, Kristoff Corten, Xavier Sala-Blanch, Admir Hadzic, and Philippe Emmanuel Gautier.
• Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium luchy88@gmail.com.
• Reg Anesth Pain Med. 2024 Jun 25.

BackgroundCurrent understanding of the mechanism of action of the pericapsular nerve group (PENG) block is primarily based on cadaver studies. We performed an imaging study in patients undergoing hip surgery to enhance the understanding of the analgesic mechanisms following a PENG block.Materials And Methods10 patients scheduled for hip surgery received an ultrasound-guided PENG block with 18 mL of 0.5% ropivacaine mixed with 2 mL of a contrast agent. After completion of the block, a high-resolution CT scan was performed to obtain a three-dimensional reconstruction of the injectate's dispersion.ResultsThe CT imaging revealed that injectate was mainly confined to the epimysium of the iliacus and the psoas muscle, with a minor spread to the hip capsule. Contrast dye was detected within the iliacus and/or the psoas muscle in all patients. No observed spread to either the subpectineal plane or the obturator foramen was detected.ConclusionOur study suggests that the analgesic effect of the PENG block may be related to the block of the branches of the femoral nerve traveling within the iliopsoas muscle without a spread pattern commensurate with the block of the obturator nerve.Trial Registration NumberClinicalTrials.gov Registry (NCT06062134).© American Society of Regional Anesthesia & Pain Medicine 2024. No commercial re-use. See rights and permissions. Published by BMJ.

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