• Br J Anaesth · Aug 2024

    Editorial

    Individualising goal-directed haemodynamic therapy: future iterations will require novel trial designs.

    • Mark R Edwards.
    • Department of Anaesthesia, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Perioperative & Critical Care Research Group, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust/University of Southampton, Southampton, UK. Electronic address: mark.edwards2@uhs.nhs.uk.
    • Br J Anaesth. 2024 Aug 1; 133 (2): 241244241-244.

    AbstractVariants of perioperative cardiac output-guided haemodynamic therapy algorithms have been tested over the last few decades, without clear evidence of effectiveness. Newer approaches have focussed on individualisation of physiological targets and have been tested in early efficacy trials. Uncertainty about the benefits remains. Adoption of novel trial designs could overcome the limitations of smaller trials of this complex intervention and accelerate the exploration of future developments.Copyright © 2024. Published by Elsevier Ltd.

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