• Gina M Piscitello, Shari Rogal, Jane Schell, Yael Schenker, and Robert M Arnold.
• Division of General Internal Medicine, Section of Palliative Care and Medical Ethics, University of Pittsburgh, Pittsburgh, PA, USA. ginapiscitello@pitt.edu.
• J Gen Intern Med. 2024 Nov 1; 39 (15): 300130083001-3008.

BackgroundArtificial intelligence (AI) algorithms are increasingly used to target patients with elevated mortality risk scores for goals-of-care (GOC) conversations.ObjectiveTo evaluate the association between the presence or absence of AI-generated mortality risk scores with GOC documentation.DesignRetrospective cross-sectional study at one large academic medical center between July 2021 and December 2022.ParticipantsHospitalized adult patients with AI-defined Serious Illness Risk Indicator (SIRI) scores indicating > 30% 90-day mortality risk (defined as "elevated" SIRI) or no SIRI scores due to insufficient data.InterventionA targeted intervention to increase GOC documentation for patients with AI-generated scores predicting elevated risk of mortality.Main MeasuresOdds ratios comparing GOC documentation for patients with elevated or no SIRI scores with similar severity of illness using propensity score matching and risk-adjusted mixed-effects logistic regression.Key ResultsAmong 13,710 patients with elevated (n = 3643, 27%) or no (n = 10,067, 73%) SIRI scores, the median age was 64 years (SD 18). Twenty-five percent were non-White, 18% had Medicaid, 43% were admitted to an intensive care unit, and 11% died during admission. Patients lacking SIRI scores were more likely to be younger (median 60 vs. 72 years, p < 0.0001), be non-White (29% vs. 13%, p < 0.0001), and have Medicaid (22% vs. 9%, p < 0.0001). Patients with elevated versus no SIRI scores were more likely to have GOC documentation in the unmatched (aOR 2.5, p < 0.0001) and propensity-matched cohorts (aOR 2.1, p < 0.0001).ConclusionsUsing AI predictions of mortality to target GOC documentation may create differences in documentation prevalence between patients with and without AI mortality prediction scores with similar severity of illness. These finding suggest using AI to target GOC documentation may have the unintended consequence of disadvantaging severely ill patients lacking AI-generated scores from receiving targeted GOC documentation, including patients who are more likely to be non-White and have Medicaid insurance.© 2024. The Author(s), under exclusive licence to Society of General Internal Medicine.

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