• Allison M Gustavson, Cynthia D Morrow, Rebecca Jl Brown, Anjum S Kaka, Catherine Sowerby, Timothy J Wilt, and Susan J Diem.
• Veterans Affairs Health Services Research and Development Center for Care Delivery and Outcomes Research, Minneapolis Veterans Affairs Healthcare System, Minneapolis, MN, USA. allison.gustavson@va.gov.
• J Gen Intern Med. 2024 Oct 1; 39 (13): 255425592554-2559.

AbstractReal-time clinical care, policy, and research decisions need real-time evidence synthesis. However, as we found during the COVID-19 pandemic, it is challenging to rapidly address key clinical and policy questions through rigorous, relevant, and usable evidence. Our objective is to present three exemplar cases of rapid evidence synthesis products from the Veterans Healthcare Administration Evidence Synthesis Program (ESP) and, in the context of these examples, outline ESP products, challenges, and lessons learned. We faced challenges in (1) balancing scientific rigor with the speed in which evidence synthesis was needed, (2) sorting through rapidly evolving large bodies of evidence, and (3) assessing the impact of evidence synthesis products on clinical care, policy, and research. We found solutions in (1) engaging stakeholders early, (2) utilizing artificial intelligence capabilities, (3) building infrastructure to establish living reviews, and (4) planning for dissemination to maximize impact.© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

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