• J. Neurol. Neurosurg. Psychiatr. · Dec 2024

    Multicenter Study

    Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy.

    • Alessandro Pezzini, Barbara Tarantino, Maria Luisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Alfonso Ciccone, DelodoviciMaria LuisaMLUnità di Neurologia, Unità di Neurologia, Ospedale di Circolo, Università dell'Insubria, Varese, Italy., Lucia Princiotta Cariddi, Simone Vidale, Maurizio Paciaroni, Cristiano Azzini, Marina Padroni, Massimo Gamba, Mauro Magoni, Massimo Del Sette, Rossana Tassi, Ivo Giuseppe de Franco, Anna Cavallini, Rocco Salvatore Calabrò, Manuel Cappellari, Elisa Giorli, Giacomo Giacalone, Corrado Lodigiani, Mara Zenorini, Francesco Valletta, Rosario Pascarella, Giorgia Abrignani, Paola Castellini, Antonio Genovese, Lilia Latte, Maria Claudia Trapasso, Ilaria Grisendi, Federica Assenza, Manuela Napoli, Claudio Moratti, Sofia Beccattini, Maurizio Acampa, Franco Valzania, Mario Grassi, Davide Gentilini, and Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) Investigators.
    • Department of Medicine and Surgery, University of Parma, Parma, Italy alessandro.pezzini@unipr.it.
    • J. Neurol. Neurosurg. Psychiatr. 2024 Dec 16; 96 (1): 959995-99.

    BackgroundWhether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain.MethodsIn the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding.Results1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17).ConclusionsStatin use appears to be unrelated to the risk of ICH recurrence.© Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.

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