• Foteini Simopoulou, George Kyrgias, Ioannis Georgakopoulos, Rafaela Avgousti, Christina Armpilia, Pantelis Skarlos, Vasiliki Softa, Kiki Theodorou, Vassilis Kouloulias, and Anna Zygogianni.
• Radiation Oncology Unit, 1st Department of Radiology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens (NKUOA), Athens, Greece.
• Medicine (Baltimore). 2024 Jun 28; 103 (26): e38529e38529.

PurposeThe current review aims to summarize the international experience of the impact of adaptive radiotherapy on dosimetry and clinical and toxicity outcomes. Additionally, it might trigger Radiation Oncologists to use ART and evaluate whether ART improves target volume coverage and/or normal tissue sparing and, consequently, therapeutic results.Materials And MethodsWe conducted an electronic literature search of PubMed/MEDLINE and ScienceDirect from January 2007 to January 2023. The search adhered to the PRISMA guidelines and employed keywords such as ART, HNC, parotid gland, and target volume. Furthermore, we examined the reference lists for studies pertinent to the present review. This study included both retrospective and prospective studies that were considered for inclusion.ConclusionART replanning appears to be a sustainable strategy to minimize toxicity by improving normal tissue sparing. Furthermore, it can enhance target volume coverage by correctly determining the specific dose to be delivered to the tumor. In conclusion, this review confirmed that ART benefits dosimetric, clinical/therapeutic, and toxicity outcomes.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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