• Intern Emerg Med · Oct 2024

    Review Case Reports

    Infections and gender: clues for diagnosis of adrenal insufficiency-a case report and a review of the literature.

    • Giacomo Grandi, Michele Di Stefano, Chiara Cebrelli, Caterina Mengoli, and Antonio Di Sabatino.
    • Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, P.le Camillo Golgi 2, 27100, Pavia, Italy.
    • Intern Emerg Med. 2024 Oct 1; 19 (7): 182118281821-1828.

    AbstractThe clinical presentation of adrenal insufficiency, a condition causing adrenal hormone deficiency, is characterised by non-specific symptoms and signs: consequently, an important diagnostic delay is often evident which correlates with an increased mortality. This case report shows how the clustering of some symptoms and signs may hamper the diagnostic suspicion for this condition: serum electrolyte alterations and weight loss, when associated to recurrent infections and, in female patients, an empty sella may further guide the clinician towards a diagnosis of adrenal insufficiency. Accordingly, a clinical approach taking into account gender medicine could improve the diagnostic workup.© 2024. The Author(s).

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