• Aline Vitali-Silva, Valéria Aparecida Bello, Regina Célia Poli, Carlos Eduardo Coral de Oliveira, Milene Valéria Lopes, Diogo Nabhan Silveira, Beatriz Bagatim Bossa, Beatriz Rabello Espinosa, Tainah Mendes Ahrens, ReicheEdna Maria VissociEMV0000-0001-6507-2839Escola de Medicina, Pontifícia Universidade Católica Do Paraná, Londrina, Brazil.Universidade Estadual de Londrina, Londrina, Brazil., and SimãoAndréa Name ColadoANC0000-0002-2073-6782Universidade Estadual de Londrina, Londrina, Brazil..
• Escola de Medicina, Pontifícia Universidade Católica Do Paraná, Londrina, Brazil.
• Eur J Pain. 2024 Jun 23.

BackgroundMigraine is a genetically determined disorder that predisposes to recurrent episodes of headache. Interleukin (IL)-18 is a pro-inflammatory cytokine that seems to play a role in migraine pathophysiology, and its genetic variants could potentially impact susceptibility to migraine.ObjectiveTo investigate the association between IL18 rs360717 and rs187238 genetic variants with migraine diagnosis and its clinical characteristics.MethodsA case-control study was conducted with 152 people with migraine and 155 healthy controls, matched by sex, age, ethnicity, and body mass index. Clinical characteristics of migraine, as well as validated questionnaires regarding disability and impact of migraine, presence of allodynia, anxiety, depression, and hyperacusis were collected. Genotyping for IL18 rs360717 and rs187238 variants was performed using real-time polymerase chain reaction (qPCR) and TaqMan™ method.ResultsThe IL18 rs360717A and rs187238G alleles were associated with increased chance of being diagnosed with migraine (OR = 1.53, 95%CI 1.05-2.24, p = 0.028 and OR = 1.46, 95%CI 1.00-2.14, p = 0.049, respectively). In the dominant model, the rs360717GA + AA genotypes were also associated with a higher chance of migraine than the GG genotype (OR = 1.69, 95%CI 1.05-2.73, p = 0.030). In women, in addition to the previous associations, there was also an effect of the variants on the chance of migraine in the codominant models and dominant models. Furthermore, among women, there was an influence on the prevalence of postdrome perception with rs360717GA + AA (OR = 3.04, 95%CI 1.10-8.42, p = 0.032) and rs187238CG + GG (OR = 2.97, 95%CI 1.08-8.21, p = 0.035).ConclusionIL18 rs360717 and rs187238 variants were associated with migraine diagnosis and postdrome symptoms, especially in women.SignificanceThis study has demonstrated that IL18 rs360717 and rs187238 variants play a role in migraine, influencing the chance of being diagnosed with migraine, particularly among women. There are prospects that IL18 variants could be considered potential genetic biomarkers for migraine.© 2024 European Pain Federation ‐ EFIC ®.

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