• Revista médica de Chile · May 2023

    Case Reports

    [Langerhans histiocytosis and panhypopituitarism in adults. Case report].

    • Cindy Carvajal Moya, Jesús Díaz Aracena, Antonio Zapata Pizarro, Elena Lisott de Moro, Edgardo Mancilla Sierpe, and Cecilia Carrasco Hartard.
    • Medicina Interna, Hospital Regional Leonardo Guzmán, Universidad de Antofagasta, Antofagasta, Chile.
    • Rev Med Chil. 2023 May 1; 151 (5): 659664659-664.

    AbstractLangerhans-cells Histiocytosis (LCH) is a rare disease characterized by the clonal proliferation of immature dendritic cells that locally or diffusely infiltrate different systems, mainly affecting children. We present the case of a 38-year-old man with a long-standing history of multiple tooth loss without association with trauma, smoking, or poor dental hygiene. Skull computed tomography (CT) showed multiple lytic jaw lesions. Jaw biopsy and immunohistochemical results were compatible with the finding of LCH. The patient evolved with polyuria, polydipsia, and nocturia, confirming the presence of diabetes insipidus and panhypopituitarism through hormonal studies. Magnetic resonance imaging (MRI) of the brain shows a hypothalamic neoplasm with infundibular involvement and an image suggestive of a pituitary granuloma. The treatment consisted of maxillobuccofacial defocusing, hormonal supplementation, chemotherapy, and radiotherapy with favorable evolution.

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