• Internal medicine · Jul 2024

    Amyloid Deposition Mainly Localized in the Basal Area of the Left Ventricle in a Patient with Amyloid Transthyretin Cardiac Amyloidosis.

    • Ryosuke Iwasaki, Hiroaki Kawano, Kensuke Fukui, Kaishi Otsuka, Shuji Arakawa, Asumi Takei, Satoki Fukae, Tsuyoshi Yoshimuta, Hirokazu Kurohama, Takashi Kudo, and Koji Maemura.
    • Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
    • Intern. Med. 2024 Jul 11.

    AbstractA 74-year-old Japanese man was admitted to our hospital for catheter ablation of paroxysmal atrial fibrillation. Transthoracic echocardiography revealed basal interventricular septal hypertrophy without apical sparing. Cardiac magnetic resonance imaging revealed late gadolinium enhancement in the hypertrophic lesions. The Kumamoto criteria was one point, and the patient had no carpal tunnel syndrome. However, technetium-99m pyrophosphate scintigraphy revealed an accumulation in the basal region of the left ventricle. A skin biopsy revealed transthyretin (TTR) amyloid deposition. A TTR gene examination revealed no variants. This case suggests that amyloid deposition in TTR may occur in the basal area of the interventricular septum.

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