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- Aoi Miyazaki, Koichi Saruwatari, Toru Yamanaka, Kenji Shiraishi, Yusuke Tomita, Hidenori Ichiyasu, and Takuro Sakagami.
- Department of Respiratory Medicine, National Hospital Organization Kumamoto Minami Hospital, Japan.
- Intern. Med. 2024 Jul 11.
AbstractOsimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is the standard first-line treatment for EGFR mutation-positive non-small-cell lung cancer (NSCLC) and demonstrates favorable disease control. Conversely, immune checkpoint inhibitors (ICIs) that target programmed cell death-1/programmed cell death ligands demonstrate a restrictive tumor response. We herein report a patient who achieved a durable response to pembrolizumab following early progression within two months of osimertinib administration for EGFR mutation-positive lung adenocarcinoma. Our findings suggest that treatment with ICIs for patients with EGFR mutation-positive NSCLC experiencing early progression to osimertinib as first-line treatment might represent a viable approach.
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