• Internal medicine · Jul 2024

    Pathological Findings of Embolus Retrieved by Mechanical Thrombectomy in Cerebral Embolism with Libman-Sacks Endocarditis: A Report of Two Cases.

    • Hiroto Kodera, Yuki Sakamoto, Junya Aoki, Ryutaro Kimura, Noriko Matsumoto, Yasuhiro Nishiyama, Shinobu Kunugi, and Kazumi Kimura.
    • Department of Neurology, Graduate School of Medicine, Nippon Medical School, Japan.
    • Intern. Med. 2024 Jul 11.

    AbstractLibman-Sacks endocarditis is an important cause of embolic stroke in systemic lupus erythematosus, although the detailed pathogenesis of stroke remains unclear. We herein report two cases of stroke with Libman-Sacks endocarditis in which the emboli were retrieved by mechanical thrombectomy. The embolus consisted of eosinophilic homogeneous acellular structures, whereas fibrin-platelet thrombi were hardly observed in the embolus. Immunohistochemistry showed immunoglobulin deposits in the embolus, suggesting that immunological mechanisms were involved in the growth of the embolus. A pathological analysis of the embolus retrieved by mechanical thrombectomy provided useful information on the etiology, leading to optimal treatment.

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