• Internal medicine · Aug 2019

    Case Reports

    Exophiala dermatitidis Fungemia Diagnosed Using Time-of-flight Mass Spectrometry during Chemotherapy for Malignant Lymphoma and Successful Treatment with Voriconazole.

    • Takashi Yoshida, Takuto Tachita, Haruna Fujinami, Yoshiko Oshima, Hirokazu Sasaki, Yoshiaki Marumo, Tomoko Narita, Asahi Ito, Masaki Ri, Shigeru Kusumoto, Takashi Ishida, Hirokazu Komatsu, and Shinsuke Iida.
    • Division of Hematology & Oncology, Nagoya City University Hospital, Japan.
    • Intern. Med. 2019 Aug 1; 58 (15): 221922242219-2224.

    AbstractInfectious diseases, including those caused by fungi, remain important issues in patients receiving malignant lymphoma chemotherapy. We herein report a rare case of Exophiala dermatitidis fungemia during chemotherapy in a 67-year-old woman admitted to our hospital. She had a fever that could not be resolved despite antifungal therapy. Yeast-like fungi were detected in blood culture samples, but biochemical identification was difficult. E. dermatitidis, a black mold, was identified using time-of-flight mass spectrometry. The patient finally improved after her treatment was switched to voriconazole. Fungal infection is difficult to diagnose and treat, but this novel approach can improve patients' outcomes.

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