• Muhammed Raşid Göksu, Zeynep Gümrükçü, Emre Balaban, Tolga Mercantepe, and Fatih Mehmet Gökçe.
• Private Practice, S Dental Polyclinic Osmaniye, Turkey.
• Injury. 2024 Oct 1; 55 (10): 111719111719.

AimThis study aimed to evaluate the effect of systemic/local use of melatonin and glatiramer acetate on regeneration in traumatic nerve injury models.Materials And MethodsA total of 42 male Wistar albino rats were randomly divided into 6 groups: healthy control (Group 1), injured control (Group 2), local melatonin (Group 3), systemic melatonin (Group 4), local glatiramer acetate (Group 5), and systemic glatiramer acetate (Group 6). In all groups, electromyography recordings of the facial nerve were obtained after surgery and before sacrifice, and the damaged nerve region was histopathologically examined after sacrifice.ResultsIn the electrophysiological evaluation, the control group had the greatest decrease in amplitude and extension in latency time following surgery than the treatment groups. Furthermore, a significant decrease in the degenerative axon count, edematous areas, and fibrotic areas as well as a significant increase in axonal surface areas was observed in all the treatment groups compared with the damage control group.ConclusionsAlthough both glatiramer acetate and melatonin are beneficial in regeneration in traumatic facial nerve injuries, it can be concluded that systemic use of melatonin can yield more positive results than glatiramer acetate and local use of both two drugs.Copyright © 2024 Elsevier Ltd. All rights reserved.

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