• Curr Med Res Opin · Aug 2024

    Randomized Controlled Trial

    Relationship between anhedonia and psychosocial functioning in post-COVID-19 condition: a post-hoc analysis.

    • Sonya Liao, Kayla M Teopiz, Angela T H Kwan, Gia Han Le, Sabrina Wong, Hana Ballum, Taeho Greg Rhee, Sebastian Badulescu, Bing Cao, Ziji Guo, Shakila Meshkat, Lee Phan, Mehala Subramaniapillai, Roger Ho, and Roger S McIntyre.
    • Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
    • Curr Med Res Opin. 2024 Aug 1; 40 (8): 140714111407-1411.

    BackgroundPost-COVID-19 condition (PCC), also known as "long COVID," is characterized by persistent symptoms, negatively affecting the well-being of individuals with PCC. Anhedonia (i.e. reduced capacity for pleasure) and compromised psychosocial functioning are notable symptoms in those with PCC. We aimed to provide insights to understand the effects of anhedonia and impaired psychosocial functioning of individuals with PCC.MethodsThis post-hoc analysis used data from an 8-week, double-blind, randomized, placebo-controlled trial which evaluated vortioxetine for cognitive deficits in individuals with PCC (Clinicaltrials.gov Identifier: NCT05047952). A total of 147 eligible participants were randomly assigned to receive vortioxetine or matching placebo over eight weeks of double-blind treatment. Our study investigated the relationship between anhedonia, assessed by the Snaith-Hamilton Pleasure Scale (SHAPS), and psychosocial functioning, measured with the Post-COVID Functional Status (PCFS) scale. The analysis was conducted using a generalized linear model, with adjustments for relevant covariates such as age, sex, education, suspected versus confirmed COVID diagnosis, MDD diagnosis, and alcohol consumption.ResultsOf the 147 participants, 143 participants had available baseline data for analysis. We observed that baseline PCFS score was statistically significantly positively correlated to baseline SHAPS score (β = 0.070, p = 0.045, 95% CI).DiscussionsOur analysis revealed a significant relationship between measures of anhedonia and psychosocial functioning in adults with PCC. Strategies that aim to improve patient-reported outcomes with PCC need to prioritize the prevention and treatment of hedonic disturbances in patients experiencing PCC.

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