• Ruth Simmons, Annabel Powell, Samreen Ijaz, Sema Mandal, Justin Shute, Yasmin Mohammadi, Michael Lattimore, Kelsey McOwat, Hannah Moore, Aisling O'Rourke, Monica Desai, John MacLeod, Asra Asgharzadeh, Zoe Ward, Peter Vickerman, Ross Harris, Graham Foster, Kirsty Roberts, and Matthew Hickman.
• UK Health Security Agency, London, United Kingdom.
• Br J Gen Pract. 2024 Jul 5.

BackgroundBirth cohort screening has been implemented in some countries to identify the potentially 'missed population' of undiagnosed chronic Hepatitis C Virus (HCV) in people who may not be found through targeted approaches.AimTo determine uptake of HCV antibody testing using an oral swab screening method, overall yield, whether those testing positive had risk markers in their primary care record, and cost per case detected.Design And SettingPilot screening study set in general practices in the Southwest, South London and Yorkshire and Humber.MethodParticipants consenting were sent an oral swab kit in the post and saliva samples were tested for antibody to HCV.Results16,436/98,396 (16.7%) patients consented and were sent an oral swab kit. 12,216 (12.4%) returned a kit, with 31 participants (yield 0.03%) testing positive for HCV antibody. 45% of those positive had a risk marker for HCV on their primary care record. Two (yield 0.002%) were confirmed RNA positive and referred for treatment, both had HCV risk markers. Cost per case detected was £16,000 per HCV antibody and £247,997 per chronic HCV.ConclusionsWide-scale screening could be delivered and identified people infected with HCV, however most of these individuals could have been detected through lower-cost targeted screening. Yield and cost per case found were substantially worse than model estimates and targeted screening studies. Birth cohort screening should not be rolled out in primary care in England.Copyright © 2024, The Authors.

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