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- Zito MarinoFedericaFPathology Unit, University of Campania "L. Vanvitelli", Naples, Italy., Roberto Bianco, Marina Accardo, Andrea Ronchi, Immacolata Cozzolino, Floriana Morgillo, Giulio Rossi, and Renato Franco.
- Pathology Unit, University of Campania "L. Vanvitelli", Naples, Italy.
- Int J Med Sci. 2019 Jan 1; 16 (7): 981989981-989.
AbstractMolecular heterogeneity is a frequent event in cancer responsible of several critical issues in diagnosis and treatment of oncologic patients. Lung tumours are characterized by high degree of molecular heterogeneity associated to different mechanisms of origin including genetic, epigenetic and non-genetic source. In this review, we provide an overview of recognized mechanisms underlying molecular heterogeneity in lung cancer, including epigenetic mechanisms, mutant allele specific imbalance, genomic instability, chromosomal aberrations, tumor mutational burden, somatic mutations. We focus on the role of spatial and temporal molecular heterogeneity involved in therapeutic implications in lung cancer patients.
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