Treatment Monitoring in Multiple Sclerosis - Efficacy and

Neuroimaging Clin. N. Am. · Aug 2024

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Treatment Monitoring in Multiple Sclerosis - Efficacy and Safety.

Magnetic resonance imaging is the most sensitive method for detecting inflammatory activity in multiple sclerosis, particularly in the brain where it reveals subclinical inflammation. Established MRI markers include contrast-enhancing lesions and active T2 lesions. ⋯ Volumetric and quantitative MRI techniques are currently limited to clinical trials and are not yet recommended for routine clinical use. Additionally, MRI is crucial for detecting complications from disease-modifying treatments and for implementing MRI-based pharmacovigilance strategies, such as in patients treated with natalizumab.

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- Nima Mahmoudi and Mike P Wattjes.
- Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.
- Neuroimaging Clin. N. Am. 2024 Aug 1; 34 (3): 439452439-452.
AbstractMagnetic resonance imaging is the most sensitive method for detecting inflammatory activity in multiple sclerosis, particularly in the brain where it reveals subclinical inflammation. Established MRI markers include contrast-enhancing lesions and active T2 lesions. Recent promising markers like slowly expanding lesions and phase rim lesions are being explored for monitoring chronic inflammation, but require further validation for clinical use. Volumetric and quantitative MRI techniques are currently limited to clinical trials and are not yet recommended for routine clinical use. Additionally, MRI is crucial for detecting complications from disease-modifying treatments and for implementing MRI-based pharmacovigilance strategies, such as in patients treated with natalizumab.Copyright © 2024 Elsevier Inc. All rights reserved.

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Treatment Monitoring in Multiple Sclerosis - Efficacy and Safety.

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