• Neuroimaging Clin. N. Am. · Aug 2024

    Review

    Decoding Gray Matter Involvement in Multiple Sclerosis via Imaging.

    • Robert Zivadinov, Ferdinand Schweser, Dejan Jakimovski, Niels Bergsland, and Michael G Dwyer.
    • Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA. Electronic address: rzivadinov@bnac.net.
    • Neuroimaging Clin. N. Am. 2024 Aug 1; 34 (3): 453468453-468.

    AbstractMultiple sclerosis (MS) is increasingly understood not only as a white matter disease but also involving both the deep and cortical gray matter (GM). GM pathology in people with MS (pwMS) includes the presence of lesions, leptomeningeal inflammation, atrophy, altered iron concentration, and microstructural changes. Studies using 7T and 3T MR imaging with optimized protocols established that GM damage is a principal driver of disease progression in pwMS. Future work is needed to incorporate the assessment of these GM imaging biomarkers into the clinical workup of pwMS and the assessment of treatment efficacy.Copyright © 2024 Elsevier Inc. All rights reserved.

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