• Adam Heilmann, Aaron Lacy, Alex Koyfman, and Brit Long.
• Department of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USA.
• Am J Emerg Med. 2024 Aug 1; 82: 174182174-182.

IntroductionBotulism is a serious condition that carries with it a high rate of morbidity and mortality.ObjectiveThis review highlights the pearls and pitfalls of botulism, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence.DiscussionBotulism is a neuromuscular disorder caused by toxin production of clostridium species bacteria and is a challenging diagnosis that mimics several other conditions. Children account for the majority of patients, with a foodborne source most common, followed by wound sources, typically from intravenous drug injection. Classically, patients with botulism develop bilateral cranial nerve palsies and symmetric, bilateral, descending paralysis. However, patients may initially present with vague symptomatology, such as weakness and dry mouth, which can make diagnosis challenging. A careful history elucidating exposures such as intravenous drug use or consumption of non-commercial canned products can help differentiate botulism from other disorders causing neuromuscular weakness. If suspected, the Centers for Disease Control should be notified to mobilize antitoxin for treatment as soon as the diagnosis is suspected even prior to confirmatory testing. Antibiotics should be avoided in these patients, as they can potentiate toxin release, unless there is a concomitant infection requiring antibiotic therapy. Patients with botulism can develop respiratory compromise requiring emergent airway management. Prolonged neuromuscular blockade from botulism will lead to a variety of symptoms that require comprehensive intensive care unit level care.ConclusionAn understanding of botulism and its many potential mimics can assist emergency clinicians in diagnosing and managing this deadly disease.Published by Elsevier Inc.

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