• Dtsch. Med. Wochenschr. · Jul 2024

    Review

    [Pathophysiology and Diagnostics of Immune Thrombocytopenia].

    • Aristoteles Giagounidis.
    • Klinik für Onkologie, Hämatologie und Palliativmedizin, Marien Hospital Düsseldorf, Düsseldorf, GERMANY.
    • Dtsch. Med. Wochenschr. 2024 Jul 1; 149 (14): 832838832-838.

    AbstractImmune thrombocytopenia (ITP) is due to autoantibodies against platelet surface antigens. ITP is considered as either primary, with no clear etiology, or as secondary ITP (drug-induced; underlying diseases). Autoantibodies lead both to loss of platelets in the spleen and/or liver but simultaneously reduce their production. Contrary to other disorders with thrombocytopenia, ITP has reduced levels of thrombopoetin. ITP remains a diagnosis of exclusion. A single defining laboratory test does not exist. Glycoprotein-specific antibodies can be detected in only about 50% of cases. Ruling out EDTA-induced pseudo thrombocytopenia is of particular relevance. Secondary causes of thrombocytopenia should be excluded through medical history (especially medication history), physical examination and possibly bone-marrow puncture.Thieme. All rights reserved.

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