• Yu Chen, Jing Hui Guo, Ya Jie Chen, Yong Huang, Cheng Zhang, Qiong Zhang, Ya Li Gong, and Jing Chen.
• State Key Laboratory of Trauma and Chemical Poisoning of China, Institute of Burn Research, Southwest Hospital (the First Affiliated Hospital), Third Military Medical University, (Army Medical University), Gao Tan Yan Street, Chongqing 400038, China.
• Burns. 2024 Sep 1; 50 (7): 179017981790-1798.

AbstractSevere burn patients frequently suffer from 1,25-Dihydroxyvitamin D3 (1,25-[OH]2-D3) deficiency. In this study, we investigated the effect of 1,25-[OH]2-D3 on early mortality post severe burn and potential underlying mechanisms. Our results indicate that 1,25-[OH]2-D3 significantly reduced early mortality in mice post severe burn injury. A decrease in serum lipopolysaccharide levels and an increase in serum superoxide dismutase activity were found after administration of 1,25-[OH]2-D3. Furthermore, 1,25-[OH]2-D3 demonstrated protective effects on both intestinal and lung histology and ameliorated lung inflammation. Its anti-inflammatory effect was further confirmed in airway epithelial cells. In conclusion, our study provides evidence that 1,25-[OH]2-D3 has a significant impact on the reduction of early mortality post severe burn injury, possibly through its ability to alleviate endotoxemia, oxidative stress, and inflammation. Our findings highlight the potential of 1,25-[OH]2-D3 to protect the intestinal mucosal barrier in the early stage following major burn injury and opens up new avenues for clinical application of 1,25-[OH]2-D3 in burn patients.Copyright © 2024 Elsevier Ltd and ISBI. All rights reserved.

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