• Dtsch. Med. Wochenschr. · Aug 2024

    Review

    [Differential diagnosis and therapy of immune thrombocytopenia].

    • Aristoteles Giagounidis.
    • Klinik für Hämatologie, Onkologie und Palliativmedizin, Marien-Hospital Düsseldorf, Deutschland.
    • Dtsch. Med. Wochenschr. 2024 Aug 1; 149 (15): 895903895-903.

    AbstractImmune thrombocytopenia is caused by autoantibodies against surface antigens on platelets. Since only about 50 % of cases will allow the identification of glycoprotein-specific antibodies, ITP remains a diagnosis of exclusion. Apart from EDTA-induced pseudo thrombocytopenia, other diseases like secondary thrombocytopenia due to medication, a large number of other disease and hereditary thrombocytopenias must be taken into account. The first-line therapy of ITP includes corticosteroids and intravenous immunoglobulins. The second line consists of thrombopoietin receptor agonists, rituximab, or splenectomy. For further lines of therapy, Fostamatinib and non-steroidal immunosuppressives are available.Thieme. All rights reserved.

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