• Clinics · Jan 2024

    Review Meta Analysis

    Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis.

    • Eduardo Carvalho de Arruda Veiga, Marise Samama, Fabio Ikeda, Giovanna Santos Cavalcanti, Amanda Sartor, Suelen Fernanda Parames, Edmund C Baracat, Joji Ueno, and JuniorJose Maria SoaresJMSLim-58 - Laboratório de Ginecologia Estrutural e Molecular da Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, S.
    • GERA Instituto de Ensino e Pesquisa em Medicina Reprodutiva de, São Paulo, SP, Brazil; Department of Obstetrics and Gynecology, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), São Paulo, SP, Brazil. Electronic address: eduardo.veiga@fm.usp.br.
    • Clinics (Sao Paulo). 2024 Jan 1; 79: 100397100397.

    BackgroundMelatonin is a hormone produced by the pineal gland and it has antioxidant properties.AimThis study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.Materials And MethodsSearch strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.ResultsThe main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).ConclusionsMelatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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