Dysregulation of Host-Pathogen Interactions in Sepsis:

Semin Respir Crit Care Med · Aug 2024

Review

Dysregulation of Host-Pathogen Interactions in Sepsis: Host-Related Factors.

Sepsis stands as a prominent contributor to sickness and death on a global scale. The most current consensus definition characterizes sepsis as a life-threatening organ dysfunction stemming from an imbalanced host response to infection. ⋯ This overview delves into the immune-related processes of sepsis, elaborating about mechanisms involved in hyperinflammation and immune suppression. Moreover, we discuss stratification of patients with sepsis based on their immune profiles and how this could impact future sepsis management.

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- Sebastiaan C M Joosten, Willem J Wiersinga, and PollTom van derTVCentre for Experimental and Molecular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.Division of Infectious Diseases, Amsterdam University Medical Center, Amsterdam, The Netherlands..
- Centre for Experimental and Molecular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.
- Semin Respir Crit Care Med. 2024 Aug 1; 45 (4): 469478469-478.
AbstractSepsis stands as a prominent contributor to sickness and death on a global scale. The most current consensus definition characterizes sepsis as a life-threatening organ dysfunction stemming from an imbalanced host response to infection. This definition does not capture the intricate array of immune processes at play in sepsis, marked by simultaneous states of heightened inflammation and immune suppression. This overview delves into the immune-related processes of sepsis, elaborating about mechanisms involved in hyperinflammation and immune suppression. Moreover, we discuss stratification of patients with sepsis based on their immune profiles and how this could impact future sepsis management.Thieme. All rights reserved.

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Dysregulation of Host-Pathogen Interactions in Sepsis: Host-Related Factors.

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