• Linda Le, Navneet Narula, Fang Zhou, Paul Smereka, Jeffrey Ordner, Neil Theise, William H Moore, Francis Girvin, Lea Azour, Andre L Moreira, David P Naidich, and Jane P Ko.
• Department of Radiology, NYU Langone Health; NYU Grossman School of Medicine, New York, NY.
• Chest. 2024 Oct 1; 166 (4): 802820802-820.

Topic ImportanceChest CT imaging holds a major role in the diagnosis of lung diseases, many of which affect the peribronchovascular region. Identification and categorization of peribronchovascular abnormalities on CT imaging can assist in formulating a differential diagnosis and directing further diagnostic evaluation.Review FindingsThe peribronchovascular region of the lung encompasses the pulmonary arteries, airways, and lung interstitium. Understanding disease processes associated with structures of the peribronchovascular region and their appearances on CT imaging aids in prompt diagnosis. This article reviews current knowledge in anatomic and pathologic features of the lung interstitium composed of intercommunicating prelymphatic spaces, lymphatics, collagen bundles, lymph nodes, and bronchial arteries; diffuse lung diseases that present in a peribronchovascular distribution; and an approach to classifying diseases according to patterns of imaging presentations. Lung peribronchovascular diseases can appear on CT imaging as diffuse thickening, fibrosis, masses or masslike consolidation, ground-glass or air space consolidation, and cysts, acknowledging that some diseases may have multiple presentations.SummaryA category approach to peribronchovascular diseases on CT imaging can be integrated with clinical features as part of a multidisciplinary approach for disease diagnosis.Copyright © 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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