• Int. J. Antimicrob. Agents · Feb 2002

    Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial

    Piperacillin 2 g/tazobactam 0.5 g is as effective as imipenem 0.5 g/cilastatin 0.5 g for the treatment of acute uncomplicated pyelonephritis and complicated urinary tract infections.

    • Kurt G Naber, Orlin Savov, and Hans C Salmen.
    • Clinic of Urology, St. Elisabeth Hospital, St. Elisabeth Strasse 23, D-94315, Straubing, Germany. naberk@klinikum-straubing.de
    • Int. J. Antimicrob. Agents. 2002 Feb 1;19(2):95-103.

    AbstractThis randomised, double-blind, multicentre trial compared piperacillin/tazobactam (2 g/0.5 g/q8h) and imipenem/cilastatin (0.5 g/0.5 g/q8h) as monotherapy in patients with acute pyelonephritis or complicated urinary tract infections. In total, 237 patients were randomised to receive either piperacillin/tazobactam (n=161) or imipenem/cilastatin (n=166). At the early follow-up (=test-of-cure-visit) 5-9 days after antibiotic therapy, clinical success was noted in 122/147 (83.0%) piperacillin/tazobactam recipients compared with 123/154 (79.9%) imipenem/cilastatin recipients, thus proving that both treatments were equally effective. On a descriptive level, an advantage of piperacillin/tazobactam was demonstrated. Microbiological success at the early follow-up was 78/135 (57.8%) for piperacillin/tazobactam and 70/144 (48.6%) for imipenem/cilastatin. These results were confirmed by equivalent success rates on the last therapy day. Both drugs were generally well tolerated.

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