• Curr Pain Headache Rep · Nov 2024

    Review

    Pain Related Quality of Life in Neurofibromatosis Type 1: A Narrative Review.

    • Karina Stech and Behnum Habibi.
    • Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. karina.stech@gmail.com.
    • Curr Pain Headache Rep. 2024 Nov 1; 28 (11): 117711831177-1183.

    Purpose Of ReviewThe purpose of this narrative review is to summarize pain symptomatology and mechanisms in neurofibromatosis type 1 (NF1), discuss the pain related quality of life impacts of NF1, and discuss the literature exploring interventions to improve quality of life.Recent FindingsChronic pain in NF1 is described as headache and non-headache pain. The literature describes mechanisms contributing to neuronal hyperexcitability in the setting of reduced neurofibromin as key contributors to pain in NF1. Pain in NF1 negatively impacts quality of life with pain interference, depression, anxiety, and cognitive functioning acting as important mediators. Mitogen-activated protein kinase (MEK) inhibitors are pharmacologic agents that interfere with pain mechanisms. Mind-body interventions improve coping skills to improve quality of life. Chronic pain in NF1 is heterogeneous with negative impacts on quality of life. New developments in pharmacological and non-pharmacological interventions offer promising approaches to pain management and quality of life improvement. Additional research is necessary to validate the use of MEK inhibitors and mind-body interventions in the treatment of NF1.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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