• S. Afr. Med. J. · Apr 2024

    Case Reports

    A tale of two kidneys, and the case for machine perfusion in South Africa.

    • N B Leech, Z Keyser, D E Du Plessis, V Soyizwapi, L Bertels, and T Du Toit.
    • Division of General Surgery, Department of Surgery, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, South Africa. nicholasbleech@gmail.com.
    • S. Afr. Med. J. 2024 Apr 24; 114 (3b): e1328e1328.

    AbstractExtended-criteria donors (ECDs) are seen as a means of addressing the shortfall in solid-organ availability for transplant. However, the use of ECD kidneys is associated with a greater risk of primary non-function compared with standard-criteria donor kidneys, and a higher discard rate has been described internationally. There seems to be a lack of consensus in the consideration of ECD kidneys for transplant, with reliance often placed on the subjective assessment of individual clinicians. The following case examines the difference in the institutional decision-making process applied to two kidneys from a single donor, and provides an argument for the use of hypothermic machine perfusion in low- to middle-income countries as an efficacious and objective means of assessing ECD kidney suitability.

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