• Intern Emerg Med · Sep 2024

    Medical occurrence and safety of SARS-CoV-2 vaccination outside of the hospital setting.

    • Fiorenza Ferrari, Federico Sodi, Fabiana Madotto, Eleonora Carlesso, Gaetano Florio, Maria Rosa Pelliccia, Dario Laquintana, Alberto Bisesti, Alessandra Piatti, Matteo Letzgus, Navpreet Tiwana, Alessandro Jachetti, Marta Mancarella, Danilo Cereda, Olivia Leoni, Catia Rosanna Borriello, Laura Chiappa, Marcello Sottocorno, Giorgio Costantino, Alberto Zanella, and Giacomo Grasselli.
    • Dipartimento Area Emergenza-Urgenza, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
    • Intern Emerg Med. 2024 Sep 1; 19 (6): 159316041593-1604.

    AbstractDuring COVID-19 pandemic, vaccination has been strongly recommended and advocated to prevent COVID-19 infection and adverse outcomes, particularly among at-risk populations. The vaccination against SARS-CoV-2 (COVAC) occurred at off-site locations capable of accommodating large crowds, distinct from the hospital setting, where a team of intensivists, emergency physicians, and nurses, ensuring prompt medical attention (medical occurrences, MO) in cases of adverse event following immunization. Our aims were to estimate the incidence of MO, and to assess its association with demographics, and vaccine characteristics. Our retrospective cohort study included all subject aged 12 years and older who received vaccinations at two large out-of-hospital vaccination hubs (Fiera Milano City, Palazzo delle Scintille), between April 12th and August 31st, 2021. Nine hundred and ninety-five thousand and twenty-eight vaccinations were administrated. MOs incidence rate was 278/100,000 doses (95% confidence interval (CI) 268-289). Most MOs were mild (86.27%) and mainly observed in subjects who received the Comirnaty vaccine; 92 MOs (3.32%) were severe and mostly occurred in recipients of the Vaxzeria vaccine. The incidence rate for hospital transfers following vaccination was 4.7/100,000 doses (95% CI 3.5-6.2) and any level of anaphylaxis occurred in 0.4 cases per 100,000 administrated doses (95% CI 0.3.-0.7). Sex, age, type of vaccine and first dose were associated with incidence of MO. Our results showed a low incidence rate in MOs after COVAC, mainly mild and support the feasibility, effectiveness and safety of vaccinations administered in hubs with a dedicated SEU located outside of the hospital setting.© 2024. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).

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