• Elizabeth Gutiérrez-Islas, Brenda Beatriz Báez-Montiel, José Luis Turabián, Margarita Bolaños-Maldonado, Juan Ramón Herrera-Ontañón, Alejandro Villarín Castro, and Francisco López de Castro.
• Medicina de Familia y Comunitaria, Unidad Docente de Atención Familiar y Comunitaria de Toledo, Toledo, España.
• Aten Primaria. 2012 Dec 1; 44 (12): 720726720-6.

AimTo examine the frequency of emotional disorders (anxiety and depression) in patients with adverse drug reactions (ADR), compared with that in patients without those disorders.Study DesignCase-control.SettingSanta María de Benquerencia Health Centre (Toledo).ParticipantsPatients over 14 years old of both sexes managed in a Primary Care Clinic.Measurements And ResultsA total of 311 patients (108 cases and 203 controls) were included, of whom 53.7% were male. The mean age was 54.1 years in cases, and 46.0 in controls (t=4.254; P<.001). Antecedents of anxiety were presented in 45.5% of cases, and those of depression in 41.7%, versus 19.7% and 15.3%, respectively, in controls (P<.001). Mean chronic illnesses were 5.8 in cases and 3.5 in controls (P<.001). Mean number of drugs consumed was 3.7 in cases and 1.7 in controls (P<.001). In the logistic regression, the probability of having had anxiety was 2.5 times higher in patients with ADR (95%CI 1.12-4.51), and the probability of having had depression was twice as likely(1.06-3.66). Drug groups with a higher number of ADR were those of the central nervous system, antibiotics and antiinflammatories.Conclusions1) ADR is associated with anxiety and depression, and it can be used as a marker of social issues. 2) Attention must be paid to patients with anxiety or depression when making out prescriptions. 3) Antibiotics, antiinflammatories and drugs acting on the central nervous system are more likely to produce ADR.Copyright © 2012 Elsevier España, S.L. All rights reserved.

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