• J. Korean Med. Sci. · Jul 2024

    Polypharmacy and Elevated Risk of Severe Adverse Events in Older Adults Based on the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database.

    • Grace Juyun Kim, Ji Sung Lee, Sujung Jang, Seonghui Lee, Seongwoo Jeon, Suehyun Lee, Ju Han Kim, and Kye Hwa Lee.
    • Big Data Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
    • J. Korean Med. Sci. 2024 Jul 22; 39 (28): e205e205.

    BackgroundOlder adults are at a higher risk of severe adverse drug events (ADEs) because of multimorbidity, polypharmacy, and lower physiological function. This study aimed to determine whether polypharmacy, defined as the use of ≥ 5 active drug ingredients, was associated with severe ADEs in this population.MethodsWe used ADE reports from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database, a national spontaneous ADE report system, from 2012 to 2021 to examine and compare the strength of association between polypharmacy and severe ADEs in older adults (≥ 65 years) and younger adults (20-64 years) using disproportionality analysis.ResultsWe found a significant association between severe ADEs of cardiac and renal/urinary Medical Dictionary for Regulatory Activities System Organ Classes (MedDRA SOC) with polypharmacy in older adults. Regarding individual-level ADEs included in these MedDRA SOCs, acute cardiac arrest and renal failure were more significantly associated with polypharmacy in older adults compared with younger adults.ConclusionThe addition of new drugs to the regimens of older adults warrants close monitoring of renal and cardiac symptoms.© 2024 The Korean Academy of Medical Sciences.

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