• Taylan Gurgenci, Cian O'Leary, David Hui, Sriram Yennu, Eduardo Bruera, Mellar Davis, Meera R Agar, Camilla Zimmermann, Jennifer Philip, Sebastiano Mercadante, Janet Hardy, William E Rosa, and Phillip Good.
• Department of Palliative and Supportive Care, Mater Health Mater Research Institute-University of Queensland, Brisbane, Queensland, Australia.
• J Palliat Med. 2024 Jul 24.

AbstractEvidence-based practice is foundational to high-quality palliative care delivery. However, the clinical trials that compose the evidence base are often methodologically imperfect. Applying their conclusions without critical application to the clinical practice context can harm patients. The tips provided can help clinicians infer judiciously from clinical trial results and avoid credulously accepting findings without critique. We suggest that statistical and mathematical expertise is unnecessary, but rather a keen curiosity about investigators' rationale for certain design choices and how these choices can affect results is key. For a more comprehensive understanding of clinical trials, this article can be used with the authors' corresponding ten tips article that focuses on designing a clinical trial.

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