• Eur. J. Clin. Invest. · Oct 2024

    Review

    Emerging clinical role of proprotein convertase subtilisin/kexin type 9 inhibition-Part two: Current and emerging concepts in the clinical use of PCSK9 inhibition.

    • Alexander M Cao Zhang, Efthymios Ziogos, Tarek Harb, Gary Gerstenblith, and Thorsten M Leucker.
    • Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    • Eur. J. Clin. Invest. 2024 Oct 1; 54 (10): e14272e14272.

    BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have emerged as a novel class of drugs with cardioprotective effects through their lipid-lowering effects.ObjectiveThis review aims to discuss existing and novel strategies of PCSK9 inhibition, providing an overview of established randomized controlled trials and ongoing outcome trials that assess the efficacy and long-term safety of PCSK9 inhibitors. It also explores the evolving role of PCSK9 beyond lipid metabolism and outlines the pleiotropic actions of PCSK9 inhibition in various disorders and future directions including novel strategies to target PCSK9.ConclusionPCSK9 inhibition shows promise not only in lipid metabolism but also in other disease processes, including atherosclerotic plaque remodeling, acute coronary syndrome, stroke, inflammation, and immune response.© 2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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