• Navdeep Tangri, Christian S Alvarez, Matthew Arnold, Salvatore Barone, Ana Cebrián, Hungta Chen, Luca De Nicola, Krister Järbrink, Naresh Kanumilli, Kean-Seng Lim, Toshiki Moriyama, Pecoits FilhoRobertoRAr... more bor Research Collaborative for Health, Ann Arbor, Michigan, USA.School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Maria Cristina Ribeiro de Castro, Rafael Santamaria, Markus P Schneider, Jean Blaise Virgitti, and Pamela Kushner. less
• Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
• Eur. J. Clin. Invest. 2024 Nov 1; 54 (11): e14282e14282.

BackgroundClinical practice guidelines for patients with chronic kidney disease (CKD) recommend regular monitoring and management of kidney function and CKD risk factors. However, the majority of patients with stage 3 CKD lack a diagnosis code, and data on the implementation of these recommendations in the real world are limited.AimTo assess the implementation of guideline-directed monitoring and management practices in the real world in patients with stage 3 CKD without a recorded diagnosis code.MethodsREVEAL-CKD (NCT04847531) is a multinational, observational study of patients with stage 3 CKD. Eligible patients had ≥2 consecutive estimated glomerular filtration rate (eGFR) measurements indicative of stage 3 CKD recorded >90 and ≤730 days apart, lacked an International Classification of Diseases 9/10 diagnosis code corresponding to CKD any time before and up to 6 months after the second eGFR measurement. Testing of key measures of care quality were assessed.ResultsThe study included 435,971 patients from 9 countries. In all countries, the prevalence of urinary albumin-creatinine ratio and albuminuria testing was low. Angiotensin-converting enzyme inhibitor, angiotensin receptor blocker and statin prescriptions were highly variable, and sodium-glucose cotransporter-2 inhibitor prescriptions remained below 21%. Blood pressure measurements were recorded in 20.2%-89.9% of patients.ConclusionsOverall, a large proportion of patients with evidence of stage 3 CKD did not receive recommended, guideline-directed monitoring and management. The variability in standard of care among countries demonstrates a clear opportunity to improve monitoring and management of these patients, most likely improving long-term outcomes.© 2024 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

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