• Hugo Pinto-Marques, Mafalda Sobra, Paolo Magistri, Sílvia Gomes da Silva, Gian Piero Guerrini, Raquel Mega, Cristiano Guidetti, João Santos Coelho, Stefano Di Sandro, and Fabrizio Di Benedetto.
• Hepato-Biliary-Pancreatic and Transplantation Centre, Curry Cabral Hospital / Local Health Unit of São José, and NOVA Medical School, Lisbon, Portugal.
• Ann. Surg. 2024 Jul 2.

ObjectiveTo report the first European series of full robotic whole liver transplantation (RLT) with technical details and future perspectives.Summary Background DataFew cases of liver transplantation with a minimally invasive approach using partial grafts have been reported so far, and no cases of robotic whole liver transplantation have been reported in the scientific literature.MethodsThe adopted technique was full robotic liver hepatectomy, followed by robotic implantation after graft introduction through a small midline incision. Patients presenting with Hepatocellular Carcinoma (HCC) in liver cirrhosis with a small caudate lobe, low degree of portal hypertension, no porto-mesenteric thrombosis, as well as low MELD patients have been considered ideal candidates.ResultsSix patients underwent RLT between February and March 2024 at Lisbon and Modena University Liver Transplant Centers. Warm ischemia time during RLT ranged between 55 and 90 min, with a total surgery duration between 440 and 710 min. The median total operative time was 595 (±111,3) minutes. Only one recipient had prolonged hyperbilirubinemia, which was safely treated. The median in-hospital stay was 7.5 days, (±4.8 days).ConclusionsRLT is a promising technique to further reduce the impact of liver transplantation thanks to smaller incision, gentle tissue manipulation, high magnification and precision for vascular and biliary anastomosis, and reduced postoperative pain. This is the first step toward the demonstration of the feasibility of minimally invasive surgery in liver transplantation, although further selection and technical refinements are needed to improve reproducibility.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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