• S Turella, J Dankiewicz, N Ben-Hamouda, K Bernhard Nilsen, J Düring, C Endisch, M Engstrøm, D Flügel, N Gaspard, A M Grejs, M Haenggi, S Haffey, L Imbach, B Johnsen, D Kemlink, C Leithner, S Legriel, H Lindehammar, G Mazzon, N Nielsen, A Peyre, B Ribalta Stanford, E Roman-Pognuz, A O Rossetti, C Schrag, A Valeriánová, P Wendel-Garcia, F Zubler, T Cronberg, E Westhall, and TTM2-trial investigators.
• Department of Clinical Sciences Lund, Clinical Neurophysiology, Lund University, Lund, Sweden.
• Resuscitation. 2024 Jul 17: 110319110319.

AimAssess the prognostic ability of a non-highly malignant and reactive EEG to predict good outcome after cardiac arrest (CA).MethodsProspective observational multicentre substudy of the "Targeted Hypothermia versus Targeted Normothermia after Out-of-hospital Cardiac Arrest Trial", also known as the TTM2-trial. Presence or absence of highly malignant EEG patterns and EEG reactivity to external stimuli were prospectively assessed and reported by the trial sites. Highly malignant patterns were defined as burst-suppression or suppression with or without superimposed periodic discharges. Multimodal prognostication was performed 96 h after CA. Good outcome at 6 months was defined as a modified Rankin Scale score of 0-3.Results873 comatose patients at 59 sites had an EEG assessment during the hospital stay. Of these, 283 (32%) had good outcome. EEG was recorded at a median of 69 h (IQR 47-91) after CA. Absence of highly malignant EEG patterns was seen in 543 patients of whom 255 (29% of the cohort) had preserved EEG reactivity. A non-highly malignant and reactive EEG had 56% (CI 50-61) sensitivity and 83% (CI 80-86) specificity to predict good outcome. Presence of EEG reactivity contributed (p < 0.001) to the specificity of EEG to predict good outcome compared to only assessing background pattern without taking reactivity into account.ConclusionNearly one-third of comatose patients resuscitated after CA had a non-highly malignant and reactive EEG that was associated with a good long-term outcome. Reactivity testing should be routinely performed since preserved EEG reactivity contributed to prognostic performance.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.

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