• Guido Mazzinari, Fernando G Zampieri, Lorenzo Ball, Niklas S Campos, Thomas Bluth, HemmesSabrine N TSNTDepartments of Intensive Care and of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Carlos Ferrando, Julian Librero, Marina Soro, Paolo Pelosi, Gama de AbreuMarceloMDepartments of Intensive Care and Resuscitation, of Cardiothoracic Anesthesia, and of Outcomes Research, Institute of Anesthesiology, Cleveland Clinic, Cleveland, Ohio., Marcus J Schultz, Ary Serpa Neto, and for REPEAT on behalf of the PROVHILO, iPROVE, and PROBESE investigators and the PROVE Network investigators.
• Department of Anesthesiology and Pain Medicine, La Fe Research Institute, Valencia, Spain; Perioperative Medicine Research Group, Valencia, Spain; and Department of Statistics and Operational Research, Universidad de Valencia, Valencia, Spain.
• Anesthesiology. 2025 Jan 1; 142 (1): 729772-97.

BackgroundThe influence of high positive end-expiratory pressure (PEEP) with recruitment maneuvers on the occurrence of postoperative pulmonary complications after surgery is still not definitively established. Bayesian analysis can help to gain further insights from the available data and provide a probabilistic framework that is easier to interpret. The objective was to estimate the posterior probability that the use of high PEEP with recruitment maneuvers is associated with reduced postoperative pulmonary complications in patients with intermediate-to-high risk under neutral, pessimistic, and optimistic expectations regarding the treatment effect.MethodsMultilevel Bayesian logistic regression analysis was performed on individual patient data from three randomized clinical trials carried out on surgical patients at intermediate to high risk for postoperative pulmonary complications. The main outcome was the occurrence of postoperative pulmonary complications in the early postoperative period. This study examined the effect of high PEEP with recruitment maneuvers versus low PEEP ventilation. Priors were chosen to reflect neutral, pessimistic, and optimistic expectations of the treatment effect.ResultsUsing a neutral, pessimistic, or optimistic prior, the posterior mean odds ratio for high PEEP with recruitment maneuvers compared to low PEEP was 0.85 (95% credible interval, 0.71 to 1.02), 0.87 (0.72 to 1.04), and 0.86 (0.71 to 1.02), respectively. Regardless of prior beliefs, the posterior probability of experiencing a beneficial effect exceeded 90%. Subgroup analysis indicated a more pronounced effect in patients who underwent laparoscopy (odds ratio, 0.67 [0.50 to 0.87]) and those at high risk for postoperative pulmonary complications (odds ratio, 0.80 [0.53 to 1.13]). Sensitivity analysis, considering severe postoperative pulmonary complications only or applying a different heterogeneity prior, yielded consistent results.ConclusionsHigh PEEP with recruitment maneuvers demonstrated a moderate reduction in the probability of postoperative pulmonary complication occurrence, with a high posterior probability of benefit observed consistently across various prior beliefs, particularly among patients who underwent laparoscopy.Copyright © 2024 American Society of Anesthesiologists. All Rights Reserved.

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