• Beijing Da Xue Xue Bao · Aug 2008

    Review

    [Progress in the study of the chemical synapse in glioma-associated epileptogenesis].

    • Hong-zan Sun, Guo-guang Fan, Gui-ling Wang, and Qi-yong Guo.
    • Department of Radiology, Shengjing Hospital of China Medical University, Shengyang, China.
    • Beijing Da Xue Xue Bao. 2008 Aug 18;40(4):446-9.

    AbstractSeizures may be the first or sometimes the only manifestation of patients with glioma in clinics. The aim of operation is to eliminate epilepsy far beyond mere resection of tumor mass. The underlying mechanisms of glioma-associated epileptogenesis are poorly understood. Recently the theory of amino-acid like neurotransmitters in chemical synapse is gradually accepted. However, the molecular mechanisms remain to be further investigated on how glutamate release is regulated and how synaptic homeostasis in peripheral neurons is kept or disturbed. So detailed studies are needed to clarify specific molecular target and provide proper evidence for optimal antiepileptic drugs in glioma-associated epileptogenesis.

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