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Comparative Study
Enrollment of sudden cardiac death victims into a limited cardiac autopsy study in the emergency department.
- K R Denninghoff.
- University of Alabama at Birmingham, Department of Emergency Medicine 35233-7013, USA.
- J Natl Med Assoc. 2000 Jan 1; 92 (1): 363836-8.
AbstractThe lack of balanced recruitment for racial and ethnic groups in research protocols is an important ethical issue. African Americans have a history of forced participation, unethical research, and unwilling human dissection/demonstration that leads to a lack of participation in clinical research. We have embarked on a study of the pathophysiology of sudden death among African Americans which requires a limited autopsy of the heart. Our objective was to improve the recruitment rate in this study when compared with historical rates seen in clinical research and organ donation. We have screened 14 and enrolled 10 African Americans with sudden death (95% CI 0.41-0.91). By addressing the concerns of the African-American community and involving qualified input in the planning stages of the study we have been able to significantly improve the recruitment rate for this important population subgroup.
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