• Gray Umbach, Ishan Kanungo, Daniel Quintana, Abrar Choudhury, Ramin Morshed, Javier Villanueva-Meyer, Philip Theodosopoulos, Stephen T Magill, Michael McDermott, David Raleigh, and Ezequiel Goldschmidt.
• Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
• World Neurosurg. 2024 Sep 1; 189: e591e597e591-e597.

Background/ObjectiveMeningioma calcification is thought to predict reduced growth potential and aggression. However, historical studies have primarily focused on correlating calcification in small meningiomas (diameter less than 2.5 cm) rather than analyzing characteristics of calcified meningiomas across all sizes. In this study, we investigate the pathologic and clinical implications of meningioma calcification.MethodsWe utilized a historical database of 342 consecutive newly diagnosed intracranial meningiomas with preoperative computed tomography and magnetic resonance imaging scans treated at a single institution from 2005 to 2019. We correlated the presence of calcification with patient demographics, grade, Mindbomb Homolog-1 index, location, volume, Simpson grade, and recurrence using both univariate and multivariate generalized linear models.ResultsOn univariate analysis, no single variable correlated with tumor calcification. Notably, neither tumor 2021 World Health Organization grade (P = 0.91) nor Mindbomb Homolog-1 index (P = 0.62) predicted calcification. After accounting for demographic characteristics and tumor volume and location, there was no significant association between 2021 World Health Organization grade (P = 0.52) and Mindbomb Homolog-1 index (P = 0.54) and calcification. Calcification had no influence on resection grade (P = 0.59) or recurrence (P = 0.80).ConclusionsIn this series, calcified meningiomas exhibited similar 2021 World Health Organization tumor grading distribution, proliferation indexes, and immediate surgical outcomes compared to their noncalcified counterparts. These findings question the historical role of using meningioma calcification as an independent guide to their management.Copyright © 2024 Elsevier Inc. All rights reserved.

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